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Article

ERAP1 is a critical regulator of inflammasome-mediated proinflammatory and ER stress responses

4 Mar 2022

Abstract excerpt

Abstract Background In addition to its role in antigen presentation, recent reports establish a new role for endoplasmic reticulum aminopeptidase 1 (ERAP1) in innate immunity; however, the mechanisms underlying these functions are not fully defined. We previously confirmed that loss of ERAP1 functions resulted in exaggerated innate immune responses in a murine in vivo model. Here, we investigated the role of...

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PMID: 35246034
DOI: 10.1186/s12865-022-00481-9

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