Personalized medicine and human genetic diversity.

doi:10.1101/cshperspect.a008581

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Article

Personalized medicine and human genetic diversity.

Cold Spring Harbor perspectives in medicine - 24 Jul 2014

Lu Yi-Fan, Goldstein David B, Angrist Misha, Cavalleri Gianpiero

Abstract excerpt

Human genetic diversity has long been studied both to understand how genetic variation influences risk of disease and infer aspects of human evolutionary history. In this article, we review historical and contemporary views of human genetic diversity, the rare and common mutations implicated in human disease susceptibility, and the relevance of genetic diversity to personalized medicine. First, we describe the...

Topics

Disease
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Humans
Precision Medicine

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Identifiers

PMID: 25059740
DOI: 10.1101/cshperspect.a008581
PMCID: PMC4143101

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