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Article

IDO1 and IDO2 non-synonymous gene variants: correlation with crohn's disease risk and clinical phenotype.

PloS one - 1 Jan 2014

Lee Alexander, Kanuri Navya, Zhang Yuanhao, Sayuk Gregory S, Li Ellen, Ciorba Matthew A

Abstract excerpt

BACKGROUND: Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. Genetic polymorphisms can confer CD risk and influence disease phenotype. Indoleamine 2,3 dioxygenase-1 (IDO1) is one of the most over-expressed genes in CD and mediates potent anti-inflammatory effects via tryptophan metabolism along the kynurenine pathway. We aimed to determine whether non-synonymous polymorphisms...

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Source

Open in PubMed Open full text

Identifiers

PMID: 25541686
DOI: 10.1371/journal.pone.0115848
PMCID: PMC4277413

Genes

IDO1
IDO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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