Article
Genetic Risk for Inflammatory Bowel Disease Is a Determinant of Crohn's Disease Development in Chronic Granulomatous Disease.
Inflammatory bowel diseases - 1 Dec 2016
Huang Chengrui, De Ravin Suk See, Paul Adam R, Heller Theo, Ho Nancy, Wu Datta Lisa, Zerbe Christa S, Marciano Beatriz E, Kuhns Douglas B, Kader Howard A, Holland Steven M, Malech Harry L, Brant Steven R
Abstract excerpt
BACKGROUND: Approximately, one-third to one-half of children with chronic granulomatous disease (CGD) develop gastrointestinal inflammation characteristic of idiopathic inflammatory bowel disease (IBD), usually Crohn's disease. We hypothesized that the overall IBD genetic risk, determined by IBD genetic risk score (GRS), might in part determine IBD development in CGD. METHODS: We reviewed medical records to...
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