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Article

DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk.

The Journal of clinical investigation - 3 May 2021

Grasberger Helmut, Magis Andrew T, Sheng Elisa, Conomos Matthew P, Zhang Min, Garzotto Lea S, Hou Guoqing, Bishu Shrinivas, Nagao-Kitamoto Hiroko, El-Zaatari Mohamad, Kitamoto Sho, Kamada Nobuhiko, Stidham Ryan W, Akiba Yasutada, Kaunitz Jonathan, Haberman Yael, Kugathasan Subra, Denson Lee A, Omenn Gilbert S, Kao John Y

Abstract excerpt

A primordial gut-epithelial innate defense response is the release of hydrogen peroxide by dual NADPH oxidase (DUOX). In inflammatory bowel disease (IBD), a condition characterized by an imbalanced gut microbiota-immune homeostasis, DUOX2 isoenzyme is the highest induced gene. Performing multiomic analyses using 2872 human participants of a wellness program, we detected a substantial burden of rare...

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Source

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Identifiers

PMID: 33651715
DOI: 10.1172/JCI141676
PMCID: PMC8087203

Genes

DUOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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