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Article

Interactions with the bifunctional interface of the transcriptional coactivator DCoH1 are kinetically regulated.

The Journal of biological chemistry - 13 Feb 2015

Wang Dongli, Coco Matthew W, Rose Robert B

Abstract excerpt

Pterin-4a-carbinolamine dehydratase (PCD) is a highly conserved enzyme that evolved a second, unrelated function in mammals, as a transcriptional coactivator. As a coactivator, PCD is known as DCoH or dimerization cofactor of the transcription factor HNF-1. These two activities are associated wit...

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PMID: 25538247
DOI: 10.1074/jbc.M114.616870
PMCID: PMC4326839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25538247-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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