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Article

Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha.

Nature structural biology - 1 Sept 2000

Rose R B, Bayle J H, Endrizzi J A, Cronk J D, Crabtree G R, Alber T

Abstract excerpt

Maturity-onset diabetes of the young type 3 (MODY3) results from mutations in the transcriptional activator hepatocyte nuclear factor-1alpha (HNF-1alpha). Several MODY3 mutations target the HNF-1alpha dimerization domain (HNF-p1), which binds the coactivator, dimerization cofactor of HNF-1 (DCoH). To define the mechanism of coactivator recognition and the basis for the MODY3 phenotype, we determined the cocrystal...

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Identifiers

PMID: 10966642
DOI: 10.1038/78966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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