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Article

Diabetes-associated mutations in a beta-cell transcription factor destabilize an antiparallel "mini-zipper" in a dimerization interface.

Proceedings of the National Academy of Sciences of the United States of America - 29 Feb 2000

Hua Q X, Zhao M, Narayana N, Nakagawa S H, Jia W, Weiss M A

Abstract excerpt

Maturity-onset diabetes of the young, a monogenic form of Type II diabetes mellitus, is most commonly caused by mutations in hepatic nuclear factor 1alpha (HNF-1alpha). Here, the dimerization motif of HNF-1alpha is shown to form an intermolecular four-helix bundle. One face contains an antiparall...

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Source

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Identifiers

PMID: 10696112
DOI: 10.1073/pnas.97.5.1999
PMCID: PMC15743

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10696112-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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