Article
B-cell repertoire responses to varicella-zoster vaccination in human identical twins.
Proceedings of the National Academy of Sciences of the United States of America - 13 Jan 2015
Wang Chen, Liu Yi, Cavanagh Mary M, Le Saux Sabine, Qi Qian, Roskin Krishna M, Looney Timothy J, Lee Ji-Yeun, Dixit Vaishali, Dekker Cornelia L, Swan Gary E, Goronzy Jörg J, Boyd Scott D
Abstract excerpt
Adaptive immune responses in humans rely on somatic genetic rearrangements of Ig and T-cell receptor loci to generate diverse antigen receptors. It is unclear to what extent an individual's genetic background affects the characteristics of the antibody repertoire used in responding to vaccination...
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