Article
Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation.
Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2011
Glanville Jacob, Kuo Tracy C, von Büdingen H-Christian, Guey Lin, Berka Jan, Sundar Purnima D, Huerta Gabriella, Mehta Gautam R, Oksenberg Jorge R, Hauser Stephen L, Cox David R, Rajpal Arvind, Pons Jaume
Abstract excerpt
A diverse antibody repertoire is essential for an effective adaptive immune response to novel molecular surfaces. Although past studies have observed common patterns of V-segment use, as well as variation in V-segment use between individuals, the relative contributions to variance from genetics, disease, age, and environment have remained unclear. Using high-throughput sequence analysis of monozygotic twins, we...
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