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Novel polymorphic and copy number diversity in the antibody IGH locus of South African individuals.

Immunogenetics - 4 Dec 2024

Marsden Alaine A, Corcoran Martin, Hedestam Gunilla Karlsson, Garrett Nigel, Karim Salim S Abdool, Moore Penny L, Kitchin Dale, Morris Lynn, Scheepers Cathrine

Abstract excerpt

The heavy chain of an antibody is crucial for mediating antigen binding. IGHV genes, which partially encode the heavy chain of antibodies, exhibit vast genetic diversity largely through polymorphism and copy number variation (CNV). These genetic variations impact population-level expression levels. In this study, we analyzed expressed antibody transcriptomes and matched germline IGHV genes from donors from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39627383
DOI: 10.1007/s00251-024-01363-7
PMCID: PMC11615098

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