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Article

IgH sequences in common variable immune deficiency reveal altered B cell development and selection.

Science translational medicine - 26 Aug 2015

Roskin Krishna M, Simchoni Noa, Liu Yi, Lee Ji-Yeun, Seo Katie, Hoh Ramona A, Pham Tho, Park Joon H, Furman David, Dekker Cornelia L, Davis Mark M, James Judith A, Nadeau Kari C, Cunningham-Rundles Charlotte, Boyd Scott D

Abstract excerpt

Common variable immune deficiency (CVID) is the most common symptomatic primary immune deficiency, affecting ~1 in 25,000 persons. These patients suffer from impaired antibody responses, autoimmunity, and susceptibility to lymphoid cancers. To explore the cellular basis for these clinical phenotypes, we conducted high-throughput DNA sequencing of immunoglobulin heavy chain gene rearrangements from 93 CVID...

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Immunodeficiency and Autoimmune Disorders

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Share to Lymphoma, B-Cell

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Source

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Identifiers

PMID: 26311730
DOI: 10.1126/scitranslmed.aab1216
PMCID: PMC4584259

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