Article
Analysis of antibody binding specificities in twin and SNP-genotyped cohorts reveals that antiviral antibody epitope selection is a heritable trait.
Immunity - 11 Jan 2022
Venkataraman Thiagarajan, Valencia Cristian, Mangino Massimo, Morgenlander William, Clipman Steven J, Liechti Thomas, Valencia Ana, Christofidou Paraskevi, Spector Tim, Roederer Mario, Duggal Priya, Larman H Benjamin
Abstract excerpt
Human immune responses to viral infections are highly variable, but the genetic factors that contribute to this variability are not well characterized. We used VirScan, a high-throughput epitope scanning technology, to analyze pan-viral antibody reactivity profiles of twins and SNP-genotyped individuals. Using these data, we determined the heritability and genomic loci associated with antibody epitope selection,...
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