Article

Nascent alt-protein chemoproteomics reveals a repressor of ribosome biogenesis

2021-06-29

Abstract excerpt

Many unannotated microproteins and alternative proteins (alt-proteins) have recently been found to be co-encoded with canonical proteins, but few of their functions are known. Motivated by the hypothesis that alt-proteins undergoing active or stress-induced synthesis could play important cellular roles, here, we developed a chemoproteomic pipeline to identify nascent alt-proteins in human cells. We identified 22 a...

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Literature Corpus work: 78ff8f98-c5bb-549b-9538-90676857ea78
DOI: 10.1101/2021.06.29.450363

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