Active destruction of defective ribosomes by a ubiquitin ligase involved in DNA repair.

Abstract excerpt

Progression of DNA replication forks through damaged DNA requires a ubiquitin ligase comprised of the cullin Rtt101, the RING finger protein Hrt1, and the adaptor protein Mms1. Rtt101 and Mms1 were implicated recently by Fujii and colleagues (pp. 963-974) in the degradation of catalytically inactive mutant 25S ribosomal RNAS (rRNAs) in mature 60S ribosomal subunits, a process that requires ubiquitin and is...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to DNA Damage
• Share to DNA Repair
• Share to Mutation