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Article

COMT gene haplotypes are closely associated with postoperative fentanyl dose in patients.

Anesthesia and analgesia - 1 Apr 2015

Zhang Fan, Tong Jianbin, Hu Jie, Zhang Hao, Ouyang Wen, Huang Dong, Tang Qiuping, Liao Qin

Abstract excerpt

BACKGROUND: Fentanyl's analgesic efficacy varies widely among individuals. The single-nucleotide polymorphisms (SNPs) of catechol-O-methyltransferase (COMT) modulate sensitivity to pain. It remains unclear, however, whether COMT genetic variability affects postoperative fentanyl analgesia in patients undergoing radical gastrectomy. METHODS: One hundred fifteen patients, ASA physical status I-III, who were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25532715
DOI: 10.1213/ANE.0000000000000563

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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