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Article

Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain.

Molecular pain - 18 Dec 2008

Rakvåg Trude T, Ross Joy R, Sato Hiroe, Skorpen Frank, Kaasa Stein, Klepstad Pål

Abstract excerpt

BACKGROUND: Genetic variation contributes to differences in pain sensitivity and response to different analgesics. Catecholamines are involved in the modulation of pain and are partly metabolized by the catechol-O-methyltransferase (COMT) enzyme. Genetic variability in the COMT gene may therefore...

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Identifiers

PMID: 19094200
DOI: 10.1186/1744-8069-4-64
PMCID: PMC2644687

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19094200-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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