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Article

Associations of catechol-O-methyltransferase (rs4680) single nucleotide polymorphisms with opioid use and dose among adults with chronic pain.

Pain - 1 Jan 2019

Hooten W Michael, Biernacka Joanna M, O'Brien Travis G, Cunningham Julie M, Black John L

Abstract excerpt

Catechol-O-methyltransferase (COMT) regulates extracellular catecholamines. A widely studied COMT single nucleotide polymorphism (rs4680) changes the translated amino acid from valine to methionine (Val158Met); the polymorphism has been shown to influence opioid use. The aims of this study were to investigate the influence of COMT Val158Met on the likelihood and dose of opioid use in adults with chronic pain....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30211780
DOI: 10.1097/j.pain.0000000000001400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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