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Article

Catechol-o-methyltransferase polymorphisms predict opioid consumption in postoperative pain.

Anesthesia and analgesia - 1 Nov 2014

Candiotti Keith A, Yang Zhe, Buric David, Arheart Kris, Zhang Yanping, Rodriguez Yiliam, Gitlin Melvin C, Carvalho Enisa, Jaraba Isabel, Wang Liyong

Abstract excerpt

BACKGROUND: Previous studies have associated the catechol-O-methyltransferase (COMT) enzyme rs4680 polymorphism with opioid consumption in the treatment of chronic cancer pain. In this study, we evaluated the association between COMT rs4680 and rs4818 polymorphisms and opioid consumption in the acute postoperative period after a nephrectomy. METHODS: Opioid consumption and pain scores were evaluated in 152...

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Share to Analgesics, Opioid
Share to Catechol O-Methyltransferase
Share to Fentanyl
Share to Genotype
Share to Nephrectomy
Share to Pain Measurement
Share to Pain, Postoperative
Share to Polymorphism, Genetic

Source

Identifiers

PMID: 25185591
DOI: 10.1213/ANE.0000000000000411

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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