Article
Semaphorin3A-induced axonal transport mediated through phosphorylation of Axin-1 by GSK3β.
Brain research - 19 Feb 2015
Hida Tomonobu, Nakamura Fumio, Usui Hiroshi, Takeuchi Kan, Yamashita Naoya, Goshima Yoshio
Abstract excerpt
The establishment of neuronal polarity is necessary for proper neuronal wiring. Semaphorin3A (Sema3A), originally identified as a repulsive axon guidance molecule, exerts a wide variety of biological functions through signaling pathways including sequential phosphorylation of collapsin response mediator protein by cyclin-dependent kinase-5 (Cdk5) and glycogen synthase kinase-3β (GSK3β). Sema3A acts on its...
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