Article
Rac3-induced neuritogenesis requires binding to Neurabin I.
Molecular biology of the cell - 1 May 2006
Orioli Donata, Colaluca Ivan N, Stefanini Miria, Riva Silvano, Dotti Carlos G, Peverali Fiorenzo A
Abstract excerpt
Rac3, a neuronal GTP-binding protein of the Rho family, induces neuritogenesis in primary neurons. Using yeast two-hybrid analysis, we show that Neurabin I, the neuronal F-actin binding protein, is a direct Rac3-interacting molecule. Biochemical and light microscopy studies indicate that Neurabin I copartitions and colocalizes with Rac3 at the growth cones of neurites, inducing Neurabin I association to the...
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