Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Giant ankyrin-B suppresses stochastic collateral axon branching through direct interaction with microtubules.

The Journal of cell biology - 3 Aug 2020

Chen Keyu, Yang Rui, Li Yubing, Zhou Jin Chuan, Zhang Mingjie

Abstract excerpt

Giant ankyrin-B (gAnkB) is a 440-kD neurospecific ankyrin-B isoform and a high-confidence target for autism mutations. gAnkB suppresses axon branching through coordination of cortical microtubules, and autism-related mutation of gAnkB results in ectopic neuronal connectivity. We identified a bipartite motif from gAnkB, which bundles and avidly binds to microtubules in vitro. This motif is composed of a module of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ankyrins
Share to Astrocytes
Share to Axons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebral Cortex

Share to Hippocampus

Share to Microtubules

Share to Protein Interaction Domains and Motifs

Share to Pseudopodia

Source

Open in PubMed Open full text

Identifiers

PMID: 32640013
DOI: 10.1083/jcb.201910053
PMCID: PMC7401806

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Giant ankyrin-B suppresses stochastic collateral axon branching through direct interaction with microtubules.PMID 32640013Read ↗

Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor Sema 3ASemantic proximity Read ↗

Neurofilament accumulation disrupts autophagy in giant axonal neuropathySemantic proximity Read ↗

Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin.Semantic proximity Read ↗

Giant axonal neuropathy: An updated perspective on its pathology and pathogenesis.Semantic proximity Read ↗

The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy.Semantic proximity Read ↗

KBP is essential for axonal structure, outgrowth and maintenance in zebrafish, providing insight into the cellular basis of Goldberg-Shprintzen syndrome.Semantic proximity Read ↗

An inherited TUBB2B mutation alters a kinesin-binding site and causes polymicrogyria, CFEOM and axon dysinnervation.Semantic proximity Read ↗

Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation.Semantic proximity Read ↗

The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neuronsSemantic proximity Read ↗

Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway.Semantic proximity Read ↗

Microtubule-Actin Crosslinking Factor 1 Is Required for Dendritic Arborization and Axon Outgrowth in the Developing Brain.Semantic proximity Read ↗

CRMP-2 binds to tubulin heterodimers to promote microtubule assembly.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.