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Article

The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches.

Molecular biology of the cell - 1 Apr 2008

Yu Wenqian, Qiang Liang, Solowska Joanna M, Karabay Arzu, Korulu Sirin, Baas Peter W

Abstract excerpt

Neurons express two different microtubule-severing proteins, namely P60-katanin and spastin. Here, we performed studies on cultured neurons to ascertain whether these two proteins participate differently in axonal branch formation. P60-katanin is more highly expressed in the neuron, but spastin is more concentrated at sites of branch formation. Overexpression of spastin dramatically enhances the formation of...

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Identifiers

PMID: 18234839
DOI: 10.1091/mbc.e07-09-0878
PMCID: PMC2291400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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