Article
Control of axon-axon attraction by Semaphorin reverse signaling.
Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2014
Hsieh Hsiao-Han, Chang Wen-Tzu, Yu Li, Rao Yong
Abstract excerpt
Semaphorin family proteins are well-known axon guidance ligands. Recent studies indicate that certain transmembrane Semaphorins can also function as guidance receptors to mediate axon-axon attraction or repulsion. The mechanisms by which Semaphorin reverse signaling modulates axon-surface affinity, however, remain unknown. In this study, we reveal a novel mechanism underlying upregulation of axon-axon attraction...
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