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Article

Spatially coordinated kinase signaling regulates local axon degeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Sept 2012

Chen Mark, Maloney Janice A, Kallop Dara Y, Atwal Jasvinder K, Tam Stephen J, Baer Kristin, Kissel Holger, Kaminker Joshua S, Lewcock Joseph W, Weimer Robby M, Watts Ryan J

Abstract excerpt

In addition to being a hallmark of neurodegenerative disease, axon degeneration is used during development of the nervous system to prune unwanted connections. In development, axon degeneration is tightly regulated both temporally and spatially. Here, we provide evidence that degeneration cues are transduced through various kinase pathways functioning in spatially distinct compartments to regulate axon...

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Identifiers

PMID: 23015435
DOI: 10.1523/JNEUROSCI.2039-12.2012
PMCID: PMC6621382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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