Article
Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican Americans.
Obesity (Silver Spring, Md.) - 1 Apr 2009
Li Xia, Allayee Hooman, Xiang Anny H, Trigo Enrique, Hartiala Jaana, Lawrence Jean M, Buchanan Thomas A, Watanabe Richard M
Abstract excerpt
Genome-wide association studies showed variation in insulin-like growth factor-2 binding protein 2 (IGF2BP2) to be associated with type 2 diabetes mellitus (T2DM). We examined a 20-kb region of IGF2BP2 for association with T2DM-related quantitative traits in Mexican American families of a proband with gestational diabetes mellitus (GDM) from the BetaGene study. We genotyped 14 single-nucleotide polymorphisms...
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