Article
Novel genes for airway wall thickness identified with combined genome-wide association and expression analyses.
American journal of respiratory and critical care medicine - 1 Mar 2015
Dijkstra Akkelies E, Postma Dirkje S, van Ginneken Bram, Wielpütz Mark O, Schmidt Michael, Becker Nikolaus, Owsijewitsch Michael, Kauczor Hans-Ulrich, de Koning Harry J, Lammers Jan W, Oudkerk Matthijs, Brandsma Corry-Anke, Bossé Yohan, Nickle David C, Sin Don D, Hiemstra Pieter S, Wijmenga Ciska, Smolonska Joanna, Zanen Pieter, Vonk Judith M, van den Berge Maarten, Boezen H Marike, Groen Harry J M
Abstract excerpt
RATIONALE: Airway wall thickness (AWT) is affected by both environmental and genetic factors and is strongly associated with airflow limitation in smaller airways. OBJECTIVES: To investigate the genetic component of AWT. METHODS: AWT was measured on low-dose computed tomography scans in male heavy smokers participating in a lung cancer screening study (n = 2,640). Genome-wide association studies on AWT were...
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