Article
Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans.
EBioMedicine - 1 Feb 2016
David Sean P, Wang Ange, Kapphahn Kristopher, Hedlin Haley, Desai Manisha, Henderson Michael, Yang Lingyao, Walsh Kyle M, Schwartz Ann G, Wiencke John K, Spitz Margaret R, Wenzlaff Angela S, Wrensch Margaret R, Eaton Charles B, Furberg Helena, Mark Brown W, Goldstein Benjamin A, Assimes Themistocles, Tang Hua, Kooperberg Charles L, Quesenberry Charles P, Tindle Hilary, Patel Manali I, Amos Christopher I, Bergen Andrew W, Swan Gary E, Stefanick Marcia L
Abstract excerpt
BACKGROUND: Genome-wide association studies have identified polymorphisms linked to both smoking exposure and risk of lung cancer. The degree to which lung cancer risk is driven by increased smoking, genetics, or gene-environment interactions is not well understood. METHODS: We analyzed associations between 28 single nucleotide polymorphisms (SNPs) previously associated with smoking quantity and lung cancer in...
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