Article

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

2015-01-08

Abstract excerpt

Prions are unconventional self-propagating proteinaceous particles, devoid of any coding nucleic acid. These proteinaceous seeds serve as templates for the conversion and replication of their benign cellular isoform. Accumulating evidence suggests that many protein aggregates can act as self-propagating templates and corrupt the folding of cognate proteins. Although aggregates can be functional under certain circu...

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Identifiers and source

Literature Corpus work: b49bc43e-9346-5efd-9fca-36cb6536ab8d
DOI: 10.3791/52321-v

Open publication

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