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Article

Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1.

Journal of molecular endocrinology - 1 Apr 2002

Bassett M H, Zhang Y, Clyne C, White P C, Rainey W E

Abstract excerpt

11beta-Hydroxylase (hCYP11B1) and aldosterone synthase (hCYP11B2) are closely related isozymes with distinct roles in cortisol and aldosterone production respectively. Aldosterone synthase catalyzes the final step in aldosterone biosynthesis and is expressed only in the zona glomerulosa of the normal adrenal. 11beta-Hydroxylase catalyzes the final reaction in the production of cortisol and is expressed at higher...

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PMID: 11932209
DOI: 10.1677/jme.0.0280125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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