Article
Salt-dependent Blood Pressure in Human Aldosterone Synthase-Transgenic Mice.
Scientific reports - 28 Mar 2017
Gu Huiying, Ma Zhizhong, Wang Jian, Zhu Timothy, Du Nicole, Shatara Adam, Yi Xin, Kowala Mark C, Du Yansheng
Abstract excerpt
Hypertension is one of the most important, preventable causes of premature morbidity and mortality in the developed world. Aldosterone is a major mineralocorticoid hormone that plays a key role in the regulation of blood pressure and is implicated in the pathogenesis of hypertension and heart failure. Aldosterone synthase (AS, cytochrome P450 11B2, cyp11B2) is the sole enzyme responsible for the production of...
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