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Article

APEX1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans.

Circulation research - 6 Jul 2012

McManus Frances, Sands William, Diver Louise, MacKenzie Scott M, Fraser Robert, Davies Eleanor, Connell John M

Abstract excerpt

RATIONALE: The genetic mechanisms underlying hypertension are unclear, but relative aldosterone excess, present in ≈10% of hypertensive patients, is known to be a heritable trait. This phenotype associates with a T/C single nucleotide polymorphism (SNP) at position -344 of the aldosterone synthas...

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Share to Cytochrome P-450 CYP11B2
Share to DNA-(Apurinic or Apyrimidinic Site) Lyase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22652909
DOI: 10.1161/CIRCRESAHA.111.262931

Genes

APEX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22652909-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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