Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mendelian genes for Parkinson's disease contribute to the sporadic forms of the disease.

Human molecular genetics - 1 Apr 2015

Spataro Nino, Calafell Francesc, Cervera-Carles Laura, Casals Ferran, Pagonabarraga Javier, Pascual-Sedano Berta, Campolongo Antònia, Kulisevsky Jaime, Lleó Alberto, Navarro Arcadi, Clarimón Jordi, Bosch Elena

Abstract excerpt

Parkinson's disease (PD) can be divided into familial (Mendelian) and sporadic forms. A number of causal genes have been discovered for the Mendelian form, which constitutes 10-20% of the total cases. Genome-wide association studies have successfully uncovered a number of susceptibility loci for sporadic cases but those only explain a small fraction (6-7%) of PD heritability. It has been observed that some genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Parkinson Disease

Share to Polymorphism, Single Nucleotide

Share to White People

Source

Identifiers

PMID: 25504046
DOI: 10.1093/hmg/ddu616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mendelian genes for Parkinson's disease contribute to the sporadic forms of the disease.PMID 25504046Read ↗

Role of mendelian genes in "sporadic" Parkinson's disease.Semantic proximity Read ↗

Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance.Semantic proximity Read ↗

Clinical Manifestations and Molecular Backgrounds of Parkinson's Disease Regarding Genes Identified From Familial and Population StudiesSemantic proximity Read ↗

From genes to proteins in mendelian Parkinson's disease: an overview.Semantic proximity Read ↗

Mendelian forms of Parkinson's disease.Semantic proximity Read ↗

Population-Specific Differences in Pathogenic Variants of Genes Associated with Monogenic Parkinson’s DiseaseSemantic proximity Read ↗

Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects.Semantic proximity Read ↗

Analysis of rare Parkinson’s disease variants in millions of peopleSemantic proximity Read ↗

Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson's Disease.Semantic proximity Read ↗

The Role of Rare Coding Variants in Parkinson's Disease GWAS LociSemantic proximity Read ↗

Analysis of rare variants of autosomal-dominant genes in a Chinese population with sporadic Parkinson's disease.Semantic proximity Read ↗

Assessing the role of polygenic background on the penetrance of monogenic forms in Parkinson’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.