Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects.

Abstract excerpt

Over the last years, a plethora of genetic findings have completely changed our views on the aetiology of Parkinson's disease (PD). Linkage studies and positional cloning strategies have identified mutations in a growing number of genes which cause monogenic autosomal-dominant or autosomal-recessive forms of the disorder. While these Mendelian forms of PD are relatively rare, high-throughput genotyping and...

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