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Analysis of rare Parkinson’s disease variants in millions of people

8 Jan 2024

Abstract excerpt

Although many rare variants have been reportedly associated with Parkinson's disease (PD), many have not been replicated or have failed to replicate. Here, we conduct a large-scale replication of rare PD variants. We assessed a total of 27,590 PD cases, 6701 PD proxies, and 3,106,080 controls from three data sets: 23andMe, Inc., UK Biobank, and AMP-PD. Based on well-known PD genes, 834 variants of interest were...

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Share to Genomic variations and chromosomal abnormalities
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PMID: 38191580
DOI: 10.1038/s41531-023-00608-8

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