Article

Assessing the role of polygenic background on the penetrance of monogenic forms in Parkinson’s disease

2021-06-09

Abstract excerpt

<h4>Background</h4> Several rare and common variants are associated with Parkinson’s disease. However, there is still an incomplete penetrance in the carriers of rare variants associated with Parkinson’s disease. To address this issue, we investigated whether a PRS calculated from significant GWAS SNPs affects the penetrance of Parkinson’s disease among carriers of rare monogenic variants in known Parkinson’s dise...

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Literature Corpus work: 81f67083-c6e2-5113-8221-14133bbd882e
DOI: 10.1101/2021.06.06.21253270

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