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Article

Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson's Disease.

Molecular neurodegeneration - 19 Apr 2016

Benitez Bruno A, Davis Albert A, Jin Sheng Chih, Ibanez Laura, Ortega-Cubero Sara, Pastor Pau, Choi Jiyoon, Cooper Breanna, Perlmutter Joel S, Cruchaga Carlos

Abstract excerpt

BACKGROUND: Most sequencing studies in Parkinson's disease (PD) have focused on either a particular gene, primarily in familial and early onset PD samples, or on screening single variants in sporadic PD cases. To date, there is no systematic study that sequences the most common PD causing genes with Mendelian inheritance [α-synuclein (SNCA), leucine-rich repeat kinase 2 (LRRK2), PARKIN, PTEN-induced putative...

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Source

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Identifiers

PMID: 27094865
DOI: 10.1186/s13024-016-0097-0
PMCID: PMC4837564

Genes

SNCA
MAPT
PINK1
PTEN

Variants

Provenance

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