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Article

Direct observation of DNA alterations induced by a DNA disruptor.

Scientific reports - 28 Apr 2022

Ohshiro Takahito, Asai Ayumu, Konno Masamitsu, Ohkawa Mayuka, Komoto Yuki, Ofusa Ken, Ishii Hideshi, Taniguchi Masateru

Abstract excerpt

DNA alterations, such as base modifications and mutations, are closely related to the activity of transcription factors and the corresponding cell functions; therefore, detection of DNA alterations is important for understanding their relationships. Particularly, DNA alterations caused by exposure to exogenous molecules, such as nucleic acid analogues for cancer therapy and the corresponding changes in cell...

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PMID: 35484163
DOI: 10.1038/s41598-022-10725-8
PMCID: PMC9050671

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