Article
A novel method for the detection of point mutation in DNA using single-base-coded CdS nanoprobes.
Biosensors & bioelectronics - 15 Apr 2009
Ye Min, Zhang Youyu, Li Haitao, Zhang Yuqin, Tan Ping, Tang Hao, Yao Shouzhuo
Abstract excerpt
A novel method for DNA point mutation detection using single-base-coded CdS nanoparticle probes is proposed. Target DNA was immobilized on core/shell Fe(3)O(4)/Au magnetic nanoparticles. Single-base-coded CdS nanoparticles, such as guanosine coded CdS (G-CdS), cytidine coded CdS (C-CdS), thymidine coded CdS (T-CdS) and adenosine coded CdS (A-CdS) were used as the probes to identify the mutation sites in DNA...
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