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Article

Single-nucleotide polymorphism detection with "wire-like" DNA probes that display quasi "on-off" digital action.

Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2005

Inouye Masahiko, Ikeda Reona, Takase Masayoshi, Tsuri Takashi, Chiba Junya

Abstract excerpt

Establishing a reliable genotyping protocol is a critical matter in post-sequence genetics. In this article, we describe a highly sensitive electrochemical detection of complementary DNAs (up to 43-mer) based on hole transport with molecular-scale, "wire-like" DNA probes. The presence of a single-base mismatch in the DNA duplexes caused a dramatic decrease in the electrochemical response. We applied this method...

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Identifiers

PMID: 16087881
DOI: 10.1073/pnas.0502078102
PMCID: PMC1183446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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