Article
An efficient DNA-fueled molecular machine for the discrimination of single-base changes.
Advanced materials (Deerfield Beach, Fla.) - 17 Sept 2014
Song Tingjie, Xiao Shiyan, Yao Dongbao, Huang Fujian, Hu Maobin, Liang Haojun
Abstract excerpt
A new strategy for single-base polymorphism (SNP) detection based on the assembly of DNA-AuNPs (gold nanoparticles) driven by a DNA-fueled molecular machine, is established and optimized. It is highly efficient, works at room temperature, and is easy to handle. A single-base change on an oligonucleotide strand is unambiguously discriminated for either SNPs or insertions and deletions (indels). The strategy is...
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