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Article

YAP/TAZ: Key Players for Rheumatoid Arthritis Severity by Driving Fibroblast Like Synoviocytes Phenotype and Fibro-Inflammatory Response.

Frontiers in immunology - 1 Jan 2021

Caire Robin, Audoux Estelle, Courbon Guillaume, Michaud Eva, Petit Claudie, Dalix Elisa, Chafchafi Marwa, Thomas Mireille, Vanden-Bossche Arnaud, Navarro Laurent, Linossier Marie-Thérèse, Peyroche Sylvie, Guignandon Alain, Vico Laurence, Paul Stephane, Marotte Hubert

Abstract excerpt

Objective: The role of YAP/TAZ, two transcriptional co-activators involved in several cancers, was investigated in rheumatoid arthritis (RA). Methods: Fibroblast like synoviocytes (FLS) from patients with RA or osteoarthritis were cultured in 2D or into 3D synovial organoids. Arthritis rat model (n=28) and colitis mouse model (n=21) were used. YAP/TAZ transcriptional activity was inhibited by verteporfin (VP)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34956224
DOI: 10.3389/fimmu.2021.791907
PMCID: PMC8695934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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