Article
SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation.
Basic research in cardiology - 13 Apr 2021
Landry Natalie M, Rattan Sunil G, Filomeno Krista L, Meier Thomas W, Meier Simon C, Foran Sarah J, Meier Claire F, Koleini Navid, Fandrich Robert R, Kardami Elissavet, Duhamel Todd A, Dixon Ian M C
Abstract excerpt
We have previously shown that overexpression of SKI, an endogenous TGF-β1 repressor, deactivates the pro-fibrotic myofibroblast phenotype in the heart. We now show that SKI also functions independently of SMAD/TGF-β signaling, by activating the Hippo tumor-suppressor pathway and inhibiting the Transcriptional co-Activator with PDZ-binding motif (TAZ or WWTR1). The mechanism(s) by which SKI targets TAZ to inhibit...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.