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Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1

28 Nov 2014

Abstract excerpt

DNA interstrand cross-links (ICLs) are highly toxic lesions associated with cancer and degenerative diseases. ICLs can be repaired by the Fanconi anemia (FA) pathway and through FA-independent processes involving the FAN1 nuclease. In this work, FAN1-DNA crystal structures and biochemical data reveal that human FAN1 cleaves DNA successively at every third nucleotide. In vitro, this exonuclease mechanism allows...

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PMID: 25430771
DOI: 10.1126/science.1258973

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