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Article

The genetic association study between polymorphisms in uncoupling protein 2 and uncoupling protein 3 and metabolic data in dogs.

BMC research notes - 11 Dec 2014

Udagawa Chihiro, Tada Naomi, Asano Junzo, Ishioka Katsumi, Ochiai Kazuhiko, Bonkobara Makoto, Tsuchida Shuichi, Omi Toshinori

Abstract excerpt

BACKGROUND: The uncoupling proteins (UCPs) in the mitochondrial inner membrane are members of the mitochondrial anion carrier protein family that play an important role in energy homeostasis. Genetic association studies have shown that human UCP2 and UCP3 variants (SNPs and indels) are associated with obesity, insulin resistance, type 2 diabetes mellitus, and metabolic syndrome. The aim of this study was to...

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Source

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Identifiers

PMID: 25495519
DOI: 10.1186/1756-0500-7-904
PMCID: PMC4295406

Genes

UCP3
UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The genetic association study between polymorphisms in uncoupling protein 2 and uncoupling protein 3 and metabolic data in dogs.PMID 25495519Read ↗

The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes.Semantic proximity Read ↗

Association and expression analyses of the Ucp2 and Ucp3 gene polymorphisms with body measurement and meat quality traits in Qinchuan cattle.Semantic proximity Read ↗

Associations between polymorphisms in the mitochondrial uncoupling proteins (UCPs) with T2DM.Semantic proximity Read ↗

Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes.Semantic proximity Read ↗

Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases.Semantic proximity Read ↗

Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study.Semantic proximity Read ↗

Structural organization and mutational analysis of the human uncoupling protein-2 (hUCP2) gene.Semantic proximity Read ↗

Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes.Semantic proximity Read ↗

Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity.Semantic proximity Read ↗

Genetic variation in uncoupling protein 3 is associated with dietary intake and body composition in females.Semantic proximity Read ↗

Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians.Semantic proximity Read ↗

Genomic organization and mutational analysis of the human UCP2 gene, a prime candidate gene for human obesity.Semantic proximity Read ↗

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