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Article

Genetic variation in uncoupling protein 3 is associated with dietary intake and body composition in females.

Metabolism: clinical and experimental - 1 Apr 2004

Damcott Coleen M, Feingold Eleanor, Moffett Susan P, Barmada M Michael, Marshall Julie A, Hamman Richard F, Ferrell Robert E

Abstract excerpt

The uncoupling proteins (UCPs) are a family of mitochondrial transport proteins that promote proton leakage across the inner mitochondrial membrane, uncoupling oxidative phosphorylation from adenosine triphosphate (ATP) production and releasing energy as heat. Variation in these genes may disrupt biochemical pathways influencing thermogenesis, energy metabolism, and fuel substrate partitioning and oxidation,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15045692
DOI: 10.1016/j.metabol.2003.11.019

Genes

UCP3
UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in uncoupling protein 3 is associated with dietary intake and body composition in females.PMID 15045692Read ↗

The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes.Semantic proximity Read ↗

The energy intake modulates the association of the -55CT polymorphism of UCP3 with body weight in type 2 diabetic patients.Semantic proximity Read ↗

Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes.Semantic proximity Read ↗

Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion.Semantic proximity Read ↗

Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study.Semantic proximity Read ↗

Effects of genetic polymorphisms of UCP2 and UCP3 on very low calorie diet-induced body fat reduction in Korean female subjects.Semantic proximity Read ↗

Genetic variants in the UCP2-UCP3 gene cluster and risk of diabetes in the Women's Health Initiative Observational Study.Semantic proximity Read ↗

Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases.Semantic proximity Read ↗

Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes.Semantic proximity Read ↗

Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability.Semantic proximity Read ↗

Single nucleotide polymorphisms linked to mitochondrial uncoupling protein genes UCP2 and UCP3 affect mitochondrial metabolism and healthy aging in female nonagenarians.Semantic proximity Read ↗

Linkage and association analyses of the UCP3 gene with obesity phenotypes in Caucasian families.Semantic proximity Read ↗

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