Article
Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study.
BMC medical genetics - 21 Sept 2009
Salopuro Titta, Pulkkinen Leena, Lindström Jaana, Kolehmainen Marjukka, Tolppanen Anna-Maija, Eriksson Johan G, Valle Timo T, Aunola Sirkka, Ilanne-Parikka Pirjo, Keinänen-Kiukaanniemi Sirkka, Tuomilehto Jaakko, Laakso Markku, Uusitupa Matti
Abstract excerpt
BACKGROUND: We explored the associations of three variants in the uncoupling protein 2 (UCP2) gene, one variant in the UCP2-UCP3 intergenic region and five variants in the uncoupling protein 3 (UCP3) gene with obesity and diabetes related traits in subjects with impaired glucose tolerance participating in Finnish Diabetes Prevention Study. Altogether 507 overweight individuals (body mass index: 31.2 +/- 4.5...
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