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Article

Epigenomic evolution in diffuse large B-cell lymphomas

20 Apr 2015

Abstract excerpt

The contribution of epigenomic alterations to tumour progression and relapse is not well characterized. Here we characterize an association between disease progression and DNA methylation in diffuse large B-cell lymphoma (DLBCL). By profiling genome-wide DNA methylation at single-base pair resolution in thirteen DLBCL diagnosis-relapse sample pairs, we show that DLBCL patients exhibit heterogeneous evolution of...

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PMID: 25891015
DOI: 10.1038/ncomms7921

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