Article
Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia.
Genome research - 1 Aug 2017
Wang Lili, Fan Jean, Francis Joshua M, Georghiou George, Hergert Sarah, Li Shuqiang, Gambe Rutendo, Zhou Chensheng W, Yang Chunxiao, Xiao Sheng, Cin Paola Dal, Bowden Michaela, Kotliar Dylan, Shukla Sachet A, Brown Jennifer R, Neuberg Donna, Alessi Dario R, Zhang Cheng-Zhong, Kharchenko Peter V, Livak Kenneth J, Wu Catherine J
Abstract excerpt
Intra-tumoral genetic heterogeneity has been characterized across cancers by genome sequencing of bulk tumors, including chronic lymphocytic leukemia (CLL). In order to more accurately identify subclones, define phylogenetic relationships, and probe genotype-phenotype relationships, we developed methods for targeted mutation detection in DNA and RNA isolated from thousands of single cells from five CLL samples....
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