Article
Exosome from chaperone-rich cell lysates-loaded dendritic cells produced by CELLine 1000 culture system exhibits potent immune activity.
Biochemical and biophysical research communications - 2 Jan 2015
Bu Ning, Wu Haiqin, Zhang Guilian, Ma Xiaoling, Zhao Ping, Zhai Nina, Xiang Li, Cao Huifang, Yang Xinli, Liu Jingjie
Abstract excerpt
Dendritic cells (DCs) pulsed with exosomes can stimulate efficient cytotoxic T-lymphocyte responses and anti-tumor immunity. However, the quantity of DC-derived exosomes (DCex) obtained from various culture systems is very low, which is a significant practical issue hampering progress in this research area and needs to be addressed. Gliomas were particularly aggressive, with high morbidity and mortality,...
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